• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
GDC-0349

GDC-0349

Product ID G1310
Cas No. 1207360-89-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $151.30 In stock
5 mg $521.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0349 is an ATP-competitive inhibitor of mTOR that exhibits anticancer chemotherpeutic activity. GDC-0349 displays pre-clinical efficacy in vitro and in vivo.

Product Info

Cas No.

1207360-89-1

Purity

≥98%

Formula

C24H32N6O3

Formula Wt.

452.55

Chemical Name

1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

IUPAC Name

1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

Synonym

GDC0349

Solubility

DMSO 91 mg/mL (201.08 mM) Ethanol 6 mg/mL (13.25 mM) Water Insoluble

Appearance

Tan to yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1310 MSDS PDF

Info Sheet

G1310 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Pei Z, Blackwood E, Liu L, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. PMID: 24900569.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9878

    Cytochalasin A

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • N0075

    Natamycin

    Polyene macrolide; ergosterol inhibitor.

    ≥98%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • A1616

    AEE-788

    Inhibitor of EGFR, HER2, VEGFR2, and FLT3.

    ≥98%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • P3209

    Piceatannol

    Polyphenolic hydroxystilbene, resveratrol deri...

    ≥99%
  • B8072

    3-tert-Butyl-5-Methoxycatechol

    BHA derivative, cellular differentiation induce...

    ≥95%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • G1658

    Gentamycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

  • D3462

    Diphenhydramine Hydrochloride

    Voltage-gated Na+ channel blocker, mAChR antago...

    ≥98%
  • C2997

    Chymostatin

    Protease inhibitor.

    ≥95% (mixture of A, B, C)
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • K1679

    (+)-Ketanserin Tartrate

    5-HT2A and TRPV1 antagonist, potential α1-adre...

    ≥98%
  • S8253

    Sunitinib Malate

    Indoline; PDGFR, VEGFR, c-KIT, FLT3, mTORC1 inh...

    ≥98%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • K0054

    Kanamycin B

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • S1607

    Secretin, rat

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • L1044

    LCL-161

    SMAC mimetic; PXR agonist, IAP inhibitor.

    ≥99%, ≥99%ee, de
  • R1627

    Regorafenib Anhydrous

    Multikinase inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only