Description
GDC-1971 is an inhibitor of SHP2. SHP2 is: Src homology region 2-containing protein tyrosine phosphatase-2. SHP2 impacts the activity of tyrosine kinase signaling and may be useful in controlling cancer growth.
GDC-1971
Product ID G124088
Cas No. 2377352-49-1
Purity ≥99%
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Product Info
| Cas No. | 2377352-49-1 |
|---|---|
| Purity | ≥99% |
| Formula | C25H26N8O |
| Formula Wt. | 454.54 |
| IUPAC Name | (3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine |
| Synonym | GDC1971 |
| Appearance | Yellow powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Punekar S, Velcheti V, Neel B, et al. The current state of the art and future trends in RAS-targeted cancer therapies. Nat Rev Clin Oncol. 2022 Oct;19(10):637-655. PMID: 36028717
Yuan X, Bu H, Zhou J, et al. Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application. J Med Chem. 2020 Oct 22;63(20):11368-11396. PMID: 32460492
Yusa S, Campbell K. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol. 2003 May 1;170(9):4539-4547. PMID: 12707331
Xu Z, Guo C, Ye Q, et al. Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization. Nat Commun. 2021 Nov 2;12(1):6310. PMID: 34728626