• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Ginsenoside Rd

Ginsenoside Rd

Product ID G3456
Cas No. 52705-93-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $306.20 In stock
10 mg $449.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginsenoside Rd is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-inflammatory, neuroprotective, anticancer, anti-metastatic, cardioprotective, and immunomodulatory activities. Ginsenoside Rd regulates secretion of IFNγ and IL-4, shifts cytokine production toward Th2 phenotype, and increases expression of BDNF and NGF in animal models of experimental autoimmune encephalitis (EAE). In other animal models, ginsenoside Rd prevents paw edema by decreasing myeloperoxidase activity and malondialdehyde levels, increasing expression of superoxide dismutase, glutathione peroxidase, and catalase, and inhibiting expression of NO, PGE2, iNOS, COX-2, and NF-κB. Ginsenoside Rd decreases infarct size, cell apoptosis, and levels of creatine kinase and lactate dehydrogenase in animal models of myocardial ischemia/reperfusion. This compound also prevents phosphorylation of tau in animal models by decreasing amyloid-β (Aβ)-induced expression and activity of GSK-3β and stimulating activity of protein phosphatase 2A (PP2A). In hepatocellular carcinoma cells, ginsenoside Rd inhibits invasion and migration by decreasing expression of matrix metalloproteinases 1, 2, and 7 (MMP1/2/7) and preventing activation of ERK, p38 MAPK, and AP-1. Additionally, ginsenoside Rd inhibits the 26S proteasome and transient receptor potential melastatin-like 7 (TRPM7) channels, inhibiting proliferation of breast cancer and gastric cancer cells.

Product Info

Cas No.

52705-93-8

Purity

≥98%

Formula

C48H82O18

Formula Wt.

947.16

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

Gypenoside VIII

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3456 MSDS PDF

Info Sheet

G3456 Info Sheet PDF

References

Zhu D, Liu M, Yang Y, et al. Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neurosci Res. 2014 Sep;92(9):1217-26. PMID: 24798871.

Zhang YX, Wang L, Xiao EL, et al. Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo. Int Immunopharmacol. 2013 Dec;17(4):1094-100. PMID: 24455777.

Wang Y, Li X, Wang X, et al. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway. PLoS One. 2013 Aug 16;8(8):e70956. PMID: 23976968.

Li L, Liu Z, Liu J, et al. Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A. Neurobiol Dis. 2013 Jun;54:320-8. PMID: 23321003.

Kim BJ. Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells. J Ginseng Res. 2013 Apr;37(2):201-9. PMID: 23717173.

Yoon JH, Choi YJ, Cha SW, et al. Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation. Phytomedicine. 2012 Feb 15;19(3-4):284-92. PMID: 21982435.

Chang TL, Ding HY, Kao YW. Role of ginsenoside Rd in inhibiting 26S proteasome activity. J Agric Food Chem. 2008 Dec 24;56(24):12011-5. PMID: 19053398.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibito...

    ≥98%
  • C2997

    Chymostatin

    Protease inhibitor.

    ≥95% (mixture of A, B, C)
  • C9880

    Cytochalasin C

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%, TLC
  • V0146

    Valsartan

    AT1 inhibitor.

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • C4000

    CK-636

    Arp2/3 inhibitor.

    ≥98%
  • C3246

    Cilostazol

    Quinoline; PDE 3B inhibitor.

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • G823720

    Gusacitinib

    SYK/JAK inhibitor

    ≥98%
  • H9802

    Hyaluronic Acid Sodium (7-10 kDA)

    Glycosaminoglycan

  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • E5217

    β-Endorphin, human

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • P3597

    Pizotyline Malate

    5-HT1A partial agonist, 5-HT2C antagonist.

    ≥98%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only