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Ginsenoside Rd

Ginsenoside Rd

Product ID G3456
Cas No. 52705-93-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $306.20 In stock
10 mg $449.10 In stock
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  • Description
  • Product Info
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Description

Ginsenoside Rd is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-inflammatory, neuroprotective, anticancer, anti-metastatic, cardioprotective, and immunomodulatory activities. Ginsenoside Rd regulates secretion of IFNγ and IL-4, shifts cytokine production toward Th2 phenotype, and increases expression of BDNF and NGF in animal models of experimental autoimmune encephalitis (EAE). In other animal models, ginsenoside Rd prevents paw edema by decreasing myeloperoxidase activity and malondialdehyde levels, increasing expression of superoxide dismutase, glutathione peroxidase, and catalase, and inhibiting expression of NO, PGE2, iNOS, COX-2, and NF-κB. Ginsenoside Rd decreases infarct size, cell apoptosis, and levels of creatine kinase and lactate dehydrogenase in animal models of myocardial ischemia/reperfusion. This compound also prevents phosphorylation of tau in animal models by decreasing amyloid-β (Aβ)-induced expression and activity of GSK-3β and stimulating activity of protein phosphatase 2A (PP2A). In hepatocellular carcinoma cells, ginsenoside Rd inhibits invasion and migration by decreasing expression of matrix metalloproteinases 1, 2, and 7 (MMP1/2/7) and preventing activation of ERK, p38 MAPK, and AP-1. Additionally, ginsenoside Rd inhibits the 26S proteasome and transient receptor potential melastatin-like 7 (TRPM7) channels, inhibiting proliferation of breast cancer and gastric cancer cells.

Product Info

Cas No.

52705-93-8

Purity

≥98%

Formula

C48H82O18

Formula Wt.

947.16

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

Gypenoside VIII

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3456 MSDS PDF

Info Sheet

G3456 Info Sheet PDF

References

Zhu D, Liu M, Yang Y, et al. Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neurosci Res. 2014 Sep;92(9):1217-26. PMID: 24798871.

Zhang YX, Wang L, Xiao EL, et al. Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo. Int Immunopharmacol. 2013 Dec;17(4):1094-100. PMID: 24455777.

Wang Y, Li X, Wang X, et al. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway. PLoS One. 2013 Aug 16;8(8):e70956. PMID: 23976968.

Li L, Liu Z, Liu J, et al. Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A. Neurobiol Dis. 2013 Jun;54:320-8. PMID: 23321003.

Kim BJ. Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells. J Ginseng Res. 2013 Apr;37(2):201-9. PMID: 23717173.

Yoon JH, Choi YJ, Cha SW, et al. Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation. Phytomedicine. 2012 Feb 15;19(3-4):284-92. PMID: 21982435.

Chang TL, Ding HY, Kao YW. Role of ginsenoside Rd in inhibiting 26S proteasome activity. J Agric Food Chem. 2008 Dec 24;56(24):12011-5. PMID: 19053398.

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