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GNE-7915

GNE-7915

Product ID G5216
Cas No. 1351761-44-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
5 mg $99.80 In stock
10 mg $152.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GNE-7915 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). GNE-7915 exhibits neuroprotective activity and is in development as a potential treatment for neurodegenerative disorders such as Parkinson’s disease.

Product Info

Cas No.

1351761-44-8

Purity

≥98%

Formula

C19H21F4N5O3

Formula Wt.

443.40

IUPAC Name

(4-{[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino}-2-fluoro-5-methoxyphenyl)(4-morpholinyl)methanone

Synonym

GNE7915

Solubility

DMSO 22 mg/mL warmed (49.61 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G5216 MSDS PDF

Info Sheet

G5216 Info Sheet PDF

Brochures

LRRK2 Flyer

References

Kavanagh ME, Doddareddy MR, Kassiou M. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6. PMID: 23721803.

Estrada AA, Liu X, Baker-Glenn C, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33. PMID: 22985112.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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