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Granuliberin R is an amphiphillic antimicrobial peptide (AMP) originally found in amphibian skin. In mast cells, granuliberin R induces histamine release and increases K+ efflux. Granuliberin also inhibits basal gingival epithelial cell proliferation in animal models, potentially through a mechanism involving suppression of mitotic activity.
| Cas No. | 64704-41-2 |
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| Purity | ≥95% |
| Formula | C69H103N19O14 |
| Formula Wt. | 1422.71 |
| IUPAC Name | N-[1-[(1-amino-3-hydroxy-1-oxopropan-2-yl)amino]-1-oxopropan-2-yl]-1-[2-[[2-[[2-[[2-[[1-[2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxamide |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nakao S, Komagoe K, Inoue T, et al. Comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells. Biochim Biophys Acta. 2011 Jan;1808(1):490-7. PMID: 20955685.
Kozakiewicz M, Godlewski A. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34. PMID: 12949612.