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GS-967

GS-967

Product ID G7200
Cas No. 1262618-39-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $180.30 In stock
25 mg $488.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GS-967 inhibits voltage-gated Na+ channels, exhibiting antiepileptic, anticonvulsant, ant anti-arrhythmic activities. GS-967 decreases the cardiac late Na+ current. In vivo, this compound decreases seizure frequency and improves survival rates. In rat hearts, GS-967 suppresses and prevents ventricular tachycardia and fibrillation.

Product Info

Cas No.

1262618-39-2

Purity

≥98%

Formula

C14H7F6N3O

Formula Wt.

347.22

Chemical Name

6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

IUPAC Name

6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine

Solubility

10 mM in DMSO, insoluble in water

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G7200 MSDS PDF

Info Sheet

G7200 Info Sheet PDF

References

Anderson LL, Thompson CH, Hawkins NA, et al. Antiepileptic activity of preferential inhibitors of persistent sodium current. Epilepsia. 2014 Aug;55(8):1274-83. PMID: 24862204.

Pezhouman A, Madahian S, Stepanyan H, et al. Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart Rhythm. 2014 Mar;11(3):492-501. PMID: 24291413.

Sicouri S, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm. 2013 Jul;10(7):1036-43. PMID: 23524321.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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