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GSK-690693

GSK-690693

Product ID G7242
Cas No. 937174-76-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $127.90 In stock
5 mg $216.20 In stock
10 mg $337.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GSK-690693 is an inhibitor of Akt that displays anticancer chemotherapeutic activity. In lung and colon cancer cells, GSK-690693 inhibits cell growth. In animal models of osteosarcoma, this compound increases survival rates and decreases tumor growth. In other transgenic animal models, GSK-690693 delays lung tumor formation, decreases cell proliferation, and induces apoptosis.

Product Info

Cas No.

937174-76-0

Purity

≥99%

Formula

C21H27N7O3

Formula Wt.

425.48

IUPAC Name

4-{2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol

Synonym

GSK690693; GSK 690693

Solubility

DMSO 39 mg/mL Water 5mg/ml Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G7242 MSDS PDF

Info Sheet

G7242 Info Sheet PDF

References

Nguyen T, Coover RA, Verghese J, et al. Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation. ACS Med Chem Lett. 2014 Mar 7;5(5):462-7. PMID: 24900862.

Carol H, Morton CL, Gorlick R, et al. Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2010 Dec 15;55(7):1329-37. PMID: 20740623.

Altomare DA, Zhang L, Deng J, et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res. 2010 Jan 15;16(2):486-96. PMID: 20075391.

Custom Order

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