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Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).
| Purity | ≥95% |
|---|---|
| Formula | C49H64N12O11 |
| Formula Wt. | 997.12 |
| IUPAC Name | (2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoic acid |
| Synonym | YPWTQRF |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Lantz I, Glämsta EL, Talbäck L, et al. Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity. FEBS Lett. 1991 Aug 5;287(1-2):39-41. PMID: 1652464.
Liebmann C, Schrader U, Brantl V. Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin. Eur J Pharmacol. 1989 Aug 3;166(3):523-6. PMID: 2553436.
Davis TP, Gillespie TJ, Porreca F. Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo. Peptides. 1989 Jul-Aug;10(4):747-51. PMID: 2587417.
Brantl V, Gramsch C, Lottspeich F, et al. Novel opioid peptides derived from hemoglobin: hemorphins. Eur J Pharmacol. 1986 Jun 17;125(2):309-10. PMID: 3743640.