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Hexamethonium bromide is a non-depolarizing neuromuscular junction (NMJ) blocker that acts as an antagonist at pre-ganglionic nicotinic acetylcholine receptors (nAChRs). Hexamethonium bromide was previously used to treat hypertension as an inhibitor of sympathetic nervous system activity but is no longer clinically used.
| Cas No. | 55-97-0 |
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| Purity | ≥98% |
| Formula | C12H30Br2N2 • xH2O |
| Formula Wt. | 362.20 |
| Chemical Name | N,N,N,N',N',N'-Hexamethyl-1,6-hexanediaminium |
| IUPAC Name | trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide |
| Synonym | Hexamethonium bromide, C-6, Bistrium bromide, Esametine, Gangliostate, Simpatoblock, Vegolysin |
| Melting Point | 274-276°C |
| Solubility | Soluble in water or alcohol. Insoluble in acetone, chloroform or ether. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Barnett AJ, Fraser JR. The mechanism of arterial hypertension: a comparison of the effects of hexamethonium bromide in hypertensive and normotensive persons. Australas Ann Med. 1954 May;3(2):152-9. PMID: 13159745.