• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Humanin, human

Humanin, human

Product ID H2980
Cas No. 330936-69-1
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $152.30 In stock
1 mg $252.00 In stock
2.5 mg $446.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Humanin is an endogenous peptide that exhibits anti-apoptotic and neuroprotective activities. Humanin is overexpressed in some cancers and could possibly be used as a biomarker. In neurons undergoing ischemia/reperfusion, humanin decreases levels of lactate dehydrogenase and malondialdehyde, decreases the formation of karyopyknotic nuclei, and increases the activity of superoxide dismutase (SOD), increasing cell viability and survival. In other cellular models, humanin activates formyl peptide receptor-like receptors 1 and 2 (FPRL1/2), inhibiting Bax-dependent apoptosis and suppressing JNK-mediated cell death. Humanin also inhibits amyloid-β (Aβ)-induced neuronal death in vitro and its effects in animal models of Alzheimer’s disease.

Product Info

Cas No.

330936-69-1

Purity

≥95%

Formula

C119H204N34O32S2

Formula Wt.

2687.28

Solubility

Soluble in formic acid (1 mg/mL), 5% acetic acid.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H2980 MSDS PDF

Info Sheet

H2980 Info Sheet PDF

References

Mottaghi-Dastjerdi N, Soltany-Rezaee-Rad M, Sepehrizadeh Z, et al. Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance. Daru. 2014 Jan 8;22(1):14. PMID: 24401285.

Zhao ST, Huang XT, Zhang C, et al. Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase. Neurochem Res. 2012 Jan;37(1):153-60. PMID: 21935731.

Zapała B, Kaczyński Ł, Kieć-Wilk B, et al. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. Pharmacol Rep. 2010 Sep-Oct;62(5):767-77. PMID: 21098860.

Niikura T, Tajima H, Kita Y. Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin. Curr Neuropharmacol. 2006 Apr;4(2):139-47. PMID: 18615127.

Zhai D, Luciano F, Zhu X, et al. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem. 2005 Apr 22;280(16):15815-24. PMID: 15661737.

Ying G, Iribarren P, Zhou Y, et al. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol. 2004 Jun 1;172(11):7078-85. PMID: 15153530.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C211324

    CFI-400945

    PLK4 inhibitor.

    ≥98%
  • C2818

    Chelerythrine Chloride

    benzophenanthridine alkaloid found in Chelidoni...

    ≥98%
  • G3457

    Ginsenoside Re

    Triterpene saponin found in species of Panax; P...

    ≥98%
  • E8657

    Evodiamine

    Indole alkaloid found in Evodia rutaecarpa; top...

    ≥98%
  • C0171

    Carboplatin

    Pt-based DNA cross-linker.

    ≥99%
  • C0250

    Calcitonin Gene Related Peptide II, human

    Calcitonin-family peptide, involved in vasodila...

    ≥95%
  • O9234

    Oxiconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • R0247

    Raltegravir

    HIV integrase inhibitor.

    ≥99%
  • Z0944

    ZCL-278

    Cdc42 inhibitor.

    ≥98%
  • M0125

    Magnolol

    Lignan found in Magnolia; GABA-A potentiator.

    ≥98%
  • P698574

    Prolylrapamycin

    Rapamycin analog

  • D183744

    Destruxin A

    Cyclic depsipeptide is a secondary metabolite i...

    ≥98%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • M5793

    Moxifloxacin Free Base

    Fluoroquinolone; topoisomerase IV, topoisomeras...

    ≥98%
  • I5354

    Iniparib

    Cysteine adduct inducer, PARP-1 inhibitor.

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • W3576

    Withaferin A

    Steroid lactone produced by Withania somnifera;...

    ≥98%
  • D3227

    Dihydromethysticin

    Kavalactone originally found in Piper methystic...

    ≥97%
  • A5162

    Amprolium Hydrochloride

    Thiamine, coccidiostat; thiamine transporter in...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only