LKT Labs

Biochemicals for Life Science Research

Hydrochlorothiazide

Product ID H9614
Cas No. 58-93-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $42.00 In stock
5 g $67.90 In stock
25 g $126.00 In stock
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Description

Hydrochlorothiazide (HCT) is an antihypertensive thiazide diuretic that is used to treat hypertension and chronic kidney disease. HCT competes for the Cl- site on the Na+/Cl- co-transporter (NCCT), decreasing reabsorption of Na+ in the distal convoluted tubule, inducing natriuresis and decreasing blood volume. HCT also partially inhibits carbonic anhydrase I in erythrocytes and vascular smooth muscle cells; this mechanism may be behind the ability of HCT to decrease peripheral vascular resistance and blood pressure. Separately, HCT may also increase reabsorption of Ca2+. This compound may also exhibit anticancer chemotherapeutic benefit in conjunction with UVA light, as it enhances production of TT dimers in vitro and in vivo.

Product Info

Cas No.

58-93-5

Purity

≥98%
Formula

C7H8ClN3O4S2
Formula Wt.

297.74
Chemical Name

6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
IUPAC Name

6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2, 4-benzothiadiazine-7-sulfonamide
Melting Point

274°C
Solubility

200 mM ethanol; 100 mM 50% ethanol
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

H9614 MSDS PDF
Info Sheet

H9614 Info Sheet PDF

References

Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

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