LKT Labs

Biochemicals for Life Science Research

Hydrocortisone 21-Acetate

Product ID H9612
Cas No. 50-03-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $48.60 In stock
5 g $144.80 In stock
10 g $260.50 In stock
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Description

Hydrocortisone is a steroid hormone that is produced in the adrenal cortex and is involved in stress signaling. Hydrocortisone is a glucocorticoid and is also known as cortisol in its endogenous form; it exhibits anti-inflammatory and immunomodulatory activities. Hydrocortisone is clinically used to treat eczema, psoriasis, gout, and severe allergic reactions. Hydrocortisone stimulates gluconeogenesis, inhibits inflammatory cytokine production, and shifts the immune response from Th1 to Th2 subtype.

Product Info

Cas No.

50-03-3
Purity

≥98%
Formula

C23H32O6
Formula Wt.

404.50
Chemical Name

(11β)11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
IUPAC Name

[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2, 6,7,8,9,11,12,14,15, 16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym

Colifoam, Cortaid, Cortifoam, Hydrocal, Lanacort, Sigmacort, Velopural
Melting Point

223°C(dec)
Solubility

Soluble in DMF and dioxane. Slightly soluble in chloroform, ethanol (4 mg/mL), methanol. ether and water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

H9612 MSDS PDF
Info Sheet

H9612 Info Sheet PDF

References

Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.

Tarchalska-Kryńska B. Glucocorticosteroids: mechanism of action, pharmacological effects, pharmacokinetics and adverse effects. Otolaryngol Pol. 1994;48 Suppl 17:41-8. PMID: 8090502.

Sluyser M. Mechanism of steroid hormone action at the cellular level. Basic Life Sci. 1975;6:79-104. PMID:168860.

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