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IC261

IC261

Product ID I0801
Cas No. 186611-52-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 In stock
25 mg $638.60 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

IC261 is most commonly known as an inhibitor of casein kinase 1. It has been shown to reduce pancreatic tumor cell growth in vitro and in vivo. In addition, it also inhibits sodium channels in human TsA cells. Furthermore, IC261 has also been found to inhibit microtubule polymerization. In inflammatory pain model mice, IC261 decreased the frequency and amplitude of spontaneous excitatory postsynaptic currents.

Product Info

Cas No.

186611-52-9

Purity

≥98%

Formula

C18H17NO4

Formula Wt.

311.12

Chemical Name

(3E)-3-(2,4,6-Trimethoxybenzylidene)-1,3-dihydro-2H-indol-2-one

IUPAC Name

(3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one

Synonym

SU5607

Solubility

Soluble in DMSO (10 mg/ml). Insoluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I0801 MSDS PDF

Info Sheet

I0801 Info Sheet PDF

References

Fohr KJ, Knippschild U, Herkommer A, et al. State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Invest New Drugs. 2017 Feb 6. Epub ahead of print. PMID: 28164251.

Stoter M, Kruger M, Banting G, et al. Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One. 2014 Jun 17;9(6):e100090. PMID: 24937750.

Kurihara T, Sakurai E, Toyomoto M, et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 2014 Mar 10;10:17. PMID: 24612480.

Cheong JK, Nguyen TH, Wang H, et al. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 2011 Jun 2;30(22):2558-2569. PMID: 21256417.

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