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Icaritin

Icaritin

Product ID I0902
Cas No. 118525-40-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.90 In stock
5 mg $123.30 In stock
25 mg $389.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Icaritin is a flavonoid compound found in Epimedium that exhibits anti-inflammatory, anticancer, and antidepressant activities; it also acts as a phytoestrogen. Icaritin may act through corticosteroid signaling, as it increases glucocorticoid receptor and BDNF mRNA in the hippocampus. In animal models of stress, icaritin prevents development of social avoidance. This compound decreases levels of pro-inflammatory cytokines IL-6 and TNF-α as well as PPARγ, GSK-3β, MCP-1, p38 JNK, c-myc, p-ERK, and p-Akt, inhibiting cell proliferation and inducing apoptosis. Additionally, icaritin shows benefit as a potential treatment for bone disease, at it stimulates osteogenic differentiation and inhibits adipogenesis in vitro.

Product Info

Cas No.

118525-40-9

Purity

≥98%

Formula

C21H20O6

Formula Wt.

368.38

Chemical Name

3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one

IUPAC Name

3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one

Solubility

MeOH

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I0902 MSDS PDF

Info Sheet

I0902 Info Sheet PDF

References

Wu X, Wu J, Xia S, et al. Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. Behav Brain Res. 2013 Sep 21;256C:602-608. PMID: 24064280.

Sheng H, Rui XF, Sheng CJ, et al. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013 Apr 23;10(6):782-9. PMID: 23630444.

Lai X, Ye Y, Sun C, et al. Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model. Int Immunopharmacol. 2013 May;16(1):41-9. PMID: 23566810.

Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013 May;97(5):617-23. PMID: 23550021.

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