• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Icaritin

Icaritin

Product ID I0902
Cas No. 118525-40-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.90 In stock
5 mg $123.30 In stock
25 mg $389.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Icaritin is a flavonoid compound found in Epimedium that exhibits anti-inflammatory, anticancer, and antidepressant activities; it also acts as a phytoestrogen. Icaritin may act through corticosteroid signaling, as it increases glucocorticoid receptor and BDNF mRNA in the hippocampus. In animal models of stress, icaritin prevents development of social avoidance. This compound decreases levels of pro-inflammatory cytokines IL-6 and TNF-α as well as PPARγ, GSK-3β, MCP-1, p38 JNK, c-myc, p-ERK, and p-Akt, inhibiting cell proliferation and inducing apoptosis. Additionally, icaritin shows benefit as a potential treatment for bone disease, at it stimulates osteogenic differentiation and inhibits adipogenesis in vitro.

Product Info

Cas No.

118525-40-9

Purity

≥98%

Formula

C21H20O6

Formula Wt.

368.38

Chemical Name

3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one

IUPAC Name

3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one

Solubility

MeOH

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I0902 MSDS PDF

Info Sheet

I0902 Info Sheet PDF

References

Wu X, Wu J, Xia S, et al. Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. Behav Brain Res. 2013 Sep 21;256C:602-608. PMID: 24064280.

Sheng H, Rui XF, Sheng CJ, et al. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013 Apr 23;10(6):782-9. PMID: 23630444.

Lai X, Ye Y, Sun C, et al. Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model. Int Immunopharmacol. 2013 May;16(1):41-9. PMID: 23566810.

Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013 May;97(5):617-23. PMID: 23550021.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E537332

    Enniatin A

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • D3448

    Dimethyl Fumarate

    Fumaric acid methyl ester; nAChR agonist, indir...

    ≥98%
  • T503720

    TMS

    Selective inhibitor of cytochrome P450 1B1 (CYP...

    ≥99%
  • A4944

    Amlexanox

    Azoxanthone derivative; S100A12 and S100A13 inh...

    ≥99%
  • A6234

    Apigenin

    Flavonoid found in various plant sources; GABA-...

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • M403007

    MK-3697

    Orexin 2 receptor antagonist

    ≥98%
  • T8004

    Tubeimoside I

    Triterpene saponin originally found in Bolboste...

    ≥96%
  • N1984

    Neuropeptide FF

    Endogenous RF-amide peptide, involved in nocice...

    ≥95%
  • I544766

    Intepirdine

    Selective 5-HT6 receptor antagonist

    ≥98%
  • C0270

    Carbamazepine

    GABA potentiator, voltage-gated Na+ and ATP-sen...

    ≥98%
  • N3452

    Nimustine Hydrochloride

    Nitrosourea, DNA cross-linker.

    ≥97%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • C6019

    C-Peptide, human

    Endogenous peptide, connects A and B chains of ...

    ≥95%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • E5220

    Enfuvirtide (T-20)

    Synthetic peptide derived from HIV-1; viral fus...

    ≥95%
  • L1340

    LDK378

    ALK and IGF-1R inhibitor.

    ≥99%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • M1564

    S-Methyl-L-cysteine

    Antioxidant found in Brassicaceae family plants...

    ≥99%
  • R3011

    Recombinant TpN 15 protein

    Recombinant protein containing Treponema pallid...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only