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Idarubicin Hydrochloride

Idarubicin Hydrochloride

Product ID I1400
Cas No. 57852-57-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $142.90 In stock
10 mg $326.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Idarubicin is an anthracycline and daunorubicin analog that exhibits anticancer chemotherapeutic activity; it is clinically used to treat leukemias. Idarubicin intercalates DNA, inhibiting topoisomerase II and inducing double-stranded DNA breaks and causing histone eviction.

Product Info

Cas No.

57852-57-0

Purity

≥98%

Formula

C26H27NO9 • HCl

Formula Wt.

533.96

Chemical Name

(7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L- lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11- trihydroxy-5,12-naphthacenedione hydrochloride

IUPAC Name

(7S,9S)-9-acetyl-7-[(2R,4S,5S, 6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8, 10-dihydro-7H-tetracene-5,12-dione;hydrochloride

Synonym

Idamycin, Zavedos

Melting Point

183-185°C

Solubility

Soluble in water and methanol.

Appearance

Orange-red powder; odorless

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I1400 MSDS PDF

Info Sheet

I1400 Info Sheet PDF

References

Eda Satana Kara H. Redox mechanism of anticancer drug idarubicin and in-situ evaluation of interaction with DNA using an electrochemical biosensor. Bioelectrochemistry. 2014 Oct;99:17-23. PMID: 24967755.

Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.

Crivellari D, Lombardi D, Spazzapan S, et al. New oral drugs in older patients: a review of idarubicin in elderly patients. Crit Rev Oncol Hematol. 2004 Feb;49(2):153-63. PMID: 15012975.

Custom Order

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