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INCB 28060 (Capmatinib) is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. In cellular models of cancer, INCB28060 inhibits cell migration and induces apoptosis, inhibiting proliferation. In animal models, this compound inhibits tumor growth.
| Cas No. | 1865733-40-9 |
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| Purity | ≥98% |
| Formula | C23H21Cl2FN6O2 |
| Formula Wt. | 503.36 |
| Chemical Name | 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloride hydrate |
| IUPAC Name | 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloride hydrate |
| Synonym | INC 280 HCl hydrate; Capmatinib Hydrochloride Hydrate; Capmatinib HCl hydrate; capmatinib dihydrochloride monohydrate |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Liu X, Wang Q, Yang G, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38. PMID: 21918175.