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Iniparib

Iniparib

Product ID I5354
Cas No. 160003-66-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $112.60 In stock
10 mg $165.40 In stock
25 mg $300.40 In stock
100 mg $976.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Iniparib was initially discovered as an inhibitor of poly(ADP-ribose) polymerase (PARP 1), but has since been found to only weakly modulate PARP in an indirect manner. The exact mechanism of iniparib is unknown, but it is known to form adducts with cysteine-containing proteins. In vitro, iniparib inhibited single-stranded DNA break repair mechanisms. Clinical trials of this compound have shown mixed results in the treatment of cancers.

Product Info

Cas No.

160003-66-7

Purity

≥98%

Formula

C7H5IN2O3

Formula Wt.

292.03

Chemical Name

4-iodo-3-nitrobenzamide

IUPAC Name

4-iodo-3-nitrobenzamide

Synonym

IND 71677; BSI-201

Appearance

Yellow Solid

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I5354 MSDS PDF

Info Sheet

I5354 Info Sheet PDF

References

Mateo J, Ong M, Tan DS, et al. Appraising iniparib, the PARP inhibitor that never was-what must we learn? Nat Rev Clin Oncol. 2013 Dec;10(12):688-96. PMID: 24129347.

Wilkinson-Ryan I, Mutch D. A review of iniparib in ovarian cancer. Expert Opin Investig Drugs. 2013 Mar;22(3):399-405. PMID: 23394483.

Ma W, Halweg CJ, Menendez D, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. PMID: 22493268

Liu X, Shi Y, Maag DX, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. PMID: 22128301.

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