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Intepirdine

Intepirdine

Product ID I544766
Cas No. 607742-69-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $68.60 In stock
5 mg $120.80 In stock
25 mg $341.30 In stock
100 mg $997.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Intepirdine is a selective 5-HT6 receptor antagonist. Lab studies have shown it has cognition enhancing effects and may be useful in the battle against Alzheimer’s and other neurodegenerative diseases.

Product Info

Cas No.

607742-69-8

Purity

≥98%

Formula

C19H19N3O2S

Formula Wt.

353.44

Chemical Name

3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline

IUPAC Name

3-(benzenesulfonyl)-8-piperazin-1-ylquinoline

Synonym

GSK-742457,SB-742457

Solubility

Insoluble in water. Soluble in DMSO (60 mg/mL), ethanol (2 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I544766 MSDS PDF

Info Sheet

I544766 Info Sheet PDF

References

Grychowska K, Sataka G, Kos T, et al. Novel 1H-pyrrolo[3,2-c]quinoline based 5-HT6 receptor antagonists with potential application for the treatment of cognitive disorders associated with Alzheimer’s disease. ACS Chem Neurosci. 2016 Jul 20;7(7):972-983. PMID: 27100049.

Higgs S, Cooper AJ, Barnes NM. The 5-HT2C receptor agonist, locaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour. Psychopharmacology (Berl). 2016 Feb;233(3):417-424. PMID: 26507195.

de Bruin NM, van Drimmelen M, Kops M, et al. Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats. Behav Brain Res. 2013 May 1;244:15-28. PMID: 23384714.

Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63(5):890-897. PMID: 22766392.

Idris N, Neill J, Grayson B, et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5HT(6) and 5-HT(2A) receptor mechanisms. Psychopharmacology (Berl). 2010 Jan;208(1):23-36. PMID: 19851757.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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