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IPI-145

IPI-145

Product ID I6132
Cas No. 1201438-56-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $155.00 Please Inquire
5 mg $264.40 Please Inquire
10 mg $392.10 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

IPI-145 is an inhibitor of p110δ PI3K that exhibits anticancer chemotherapeutic, immunosuppressive, and anti-inflammatory activities. In clinical trials, IPI-145 displays potential benefit in the treatment of chronic lymphocytic leukemia (CLL). IPI-145 inhibits proliferation of B and T cells, inhibits neutrophil migration, and prevents basophil activation in vitro. It also induces apoptosis in CLL cells. In animal models of inflammatory diseases, IPI-145 decreases levels of matrix metalloproteinase 13 (MMP13) and IL-17, inhibiting Th17 T cell differentiation and decreasing arthritis severity and progression.

Product Info

Cas No.

1201438-56-3

Purity

≥98%

Formula

C22H17ClN6O

Formula Wt.

416.86

IUPAC Name

8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-one

Synonym

INK1197, Duvelisib

Solubility

DMSO 83 mg/mL (199.1 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I6132 MSDS PDF

Info Sheet

I6132 Info Sheet PDF

References

Balakrishnan K, Peluso M, Fu M, et al. The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL. Leukemia. 2015 Apr 28. [Epub ahead of print]. PMID: 25917267.

IPI-145 Shows Promise in CLL Patients. Cancer Discov. 2014 Feb;4(2):136. PMID: 24501284.

Boyle DL, Kim HR, Topolewski K, et al. Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. PMID: 24244039.

Winkler DG, Faia KL, DiNitto JP, et al. PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74. PMID: 24211136.

Custom Order

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