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Irinotecan Hydrochloride Trihydrate

Irinotecan Hydrochloride Trihydrate

Product ID I6933
Cas No. 136572-09-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.00 In stock
10 mg $132.60 In stock
25 mg $204.30 In stock
100 mg $343.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Irinotecan is an analog of camptothecin that is used clinically to treat colon and ovarian cancers, among others. Irinotecan exhibits anticancer chemotherapeutic, anti-angiogenic, and immunosuppressive activities. Irinotecan inhibits DNA topoisomerase I and sensitizes tumors to the effects of radiation. In glioma models, irinotecan decreases the number of tumor vessels and decreases expression of VEGF and HIF-1α, inhibiting tumor growth. Irinotecan also moderates inhibition of dendritic cell differentiation and may produce cholinergic side effects, suggesting potential inhibition of acetylcholinesterase (AChE) as well.

Product Info

Cas No.

136572-09-3

Purity

≥98%

Formula

C33H38N4O6 • HCl • 3H2O

Formula Wt.

677.19

Chemical Name

[1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate

IUPAC Name

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride

Synonym

Irinotecan hydrochloride trihydrate, Camptosar, Campto, CPT-11

Melting Point

256.5°C

Solubility

Slightly soluble in water (25 mg/mL), ethanol (7 mg/mL), chloroform. DMSO (100 mg/mL)

Appearance

Pale Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I6933 MSDS PDF

Info Sheet

I6933 Info Sheet PDF

References

Hu J, Kinn J, Zirakzadeh AA, et al. The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation. Clin Exp Immunol. 2013 Jun;172(3):490-9. PMID: 23600838.

Pan P, Li Y, Yu H, et al. Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches. J Chem Inf Model. 2013 Apr 22;53(4):997-1006. PMID: 23521602.

Chen AY, Chen PM, Chen YJ. DNA topoisomerase I drugs and radiotherapy for lung cancer. J Thorac Dis. 2012 Aug;4(4):390-7. PMID: 22934142.

Chintala S, Tóth K, Cao S, et al. Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha. Cancer Chemother Pharmacol. 2010 Oct;66(5):899-911. PMID: 20066420.

Dodds HM, Rivory LP. The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11). Mol Pharmacol. 1999 Dec;56(6):1346-53. PMID: 10570064.

Custom Order

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  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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