Description
Isoniazid is an antibacterial compound that displays efficacy against Mycobacterium and is clinically used to treat tuberculosis. Isoniazid inhibits InhA, an NADH-dependent enoyl-coA reductase.
Isoniazid
Product ID I7341
Cas No. 54-85-3
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 54-85-3 |
|---|---|
| Purity | ≥98% |
| Formula | C6H7N3O |
| Formula Wt. | 137.14 |
| Chemical Name | 4-Pyridinecarboxylic acid, hydrazide |
| IUPAC Name | pyridine-4-carbohydrazide |
| Synonym | Isonicotinoylhydrazine, Rimitsid, Tubazid, Cotinazin, Dinacrin, Ditubin, Hycozid. |
| Melting Point | 170-173°C |
| Solubility | Soluble in water (125 mg/mL, DMSO, methanol and ethanol (20 mg/mL). |
| Appearance | White Crystal Powder |
Shipping and Storage
| Store Temp | Ambient |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Bernardes-Génisson V, Deraeve C, Chollet A, et al. Isoniazid: an update on the multiple mechanisms for a singular action. Curr Med Chem. 2013;20(35):4370-85. PMID: 23931278.
Argyrou A, Vetting MW, Blanchard JS. New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. J Am Chem Soc. 2007 Aug 8;129(31):9582-3. PMID: 17636923.
Oliveira JS, Vasconcelos IB, Moreira IS, et al. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Curr Drug Targets. 2007 Mar;8(3):399-411. PMID: 17348833.