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IWP-2 is an inhibitor of PORCN that inhibits Wnt signaling, exhibiting anticancer activity. IWP-2 increases activity of caspases 3 and 7, inhibiting proliferation, migration, and invasion of gastric cancer cells and colorectal cancer cells.
| Cas No. | 686770-61-6 |
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| Purity | ≥98% |
| Formula | C22H18N4O2S3 |
| Formula Wt. | 466.60 |
| Chemical Name | N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide |
| IUPAC Name | N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide |
| Synonym | IWP2 |
| Solubility | DMF 22 mg/mL warmed (47.14 mM) DMSO 4 mg/mL warmed (8.57 mM) Water Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet | |
| Brochures |
Frewer KA, Sanders AJ, Owen S, et al. A role for WISP2 in colorectal cancer cell invasion and motility. Cancer Genomics Proteomics. 2013 Jul-Aug;10(4):187-96. PMID: 23893926.
Mo ML, Li MR, Chen Z, et al. Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncol Lett. 2013 May;5(5):1719-1723. PMID: 23761839.