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JNJ-26854165

JNJ-26854165

Product ID J5237
Cas No. 881202-45-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $117.20 In stock
5 mg $211.10 In stock
25 mg $633.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

JNJ-26854165 is an inhibitor of E3 ligase MDM2 that also indirectly activates p53. This compound exhibits anticancer chemotherapeutic activity, decreasing survival of various cancer cell lines and delaying tumor growth in animal models. JNJ-26854165 also induces S-phase cell cycle arrest and decreases cholesterol efflux and transport in mantle cell lymphoma and multiple myeloma cells.

Product Info

Cas No.

881202-45-5

Purity

≥98%

Formula

C21H20N4

Formula Wt.

328.42

IUPAC Name

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

Synonym

Serdemetan, JNJ26854165, JNJ 26854165

Solubility

DMSO Solubility: 66 mg/mL (200.96 mM)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J5237 MSDS PDF

Info Sheet

J5237 Info Sheet PDF

References

Jones RJ, Gu D, Bjorklund CC, et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther. 2013 Sep;346(3):381-92. Erratum in: J Pharmacol Exp Ther. 2013 Nov;347(2):540. PMID: 23820125.

Chargari C, Leteur C, Angevin E, et al. Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts. Cancer Lett. 2011 Dec 22;312(2):209-18. PMID: 21937165.

Kojima K, Burks JK, Arts J, et al. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 2010 Sep;9(9):2545-57. PMID: 20736344.

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