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Kanamycin B

Kanamycin B

Product ID K0054
Cas No. 4696-76-8
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $53.20 In stock
250 mg $132.60 In stock
1 g $357.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Kanamycin B is an aminoglycoside antibiotic that binds the bacterial 16s rRNA subunit, inhibiting translocation and degrading target RNA; it displays antibacterial efficacy against gram negative bacteria. Kanamycin also inhibits formation of the initiation complex. In cardiac pacemaker cells, kanamycin B decreases action potential amplitude, blocking slow Ca2+ currents and modulating outward K+ currents. Kanamycin B also inhibits mammalian RNA splicing.

Product Info

Cas No.

4696-76-8

Purity

≥98%

Formula

C18H37N5O10

Formula Wt.

483.51

Chemical Name

O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1- 4)-O-(2,6-diamino-2,6-dideoxy-alpha-D-gluco- pyranosyl-(1-6))-2-deoxy-D-Streptamine

IUPAC Name

(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4, 6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane- 3,4-diol

Synonym

Bekanamycin, NK-1006, Nebramycin V.

Melting Point

178-182°C (dec)

Solubility

Soluble in water or formamide. Slightly soluble in chloroform, isopropyl alcohol.

Appearance

Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

K0054 MSDS PDF

Info Sheet

K0054 Info Sheet PDF

References

Patwardhan A, Cowan JA. Influence of charge and structure on the coordination chemistry of copper aminoglycosides. Dalton Trans. 2011 Feb 28;40(8):1795-801. PMID: 21218243.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Morales MA, Castrillon JL, Hernandez DA. Effects of bekanamycin and dibekacin on the electrical activity of cardiac pacemaker cells. Arch Med Res. 1993 Winter;24(4):339-45. PMID: 8118157.

Custom Order

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