Description
L-selectin is an adhesion molecule expressed on cells such as neutrophils that allows those cells to attach to other cells and surfaces via the binding of high endothelial venule (HEV) ligands. Non-steroidal anti-inflammatory drugs (NSAIDs) downregulate expression of L-selectin in a manner dependent upon ROS signaling. Calmodulin and PKC also bind L-selectin, regulating shedding activity.