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LCL-161

LCL-161

Product ID L1044
Cas No. 1005342-46-0
Purity ≥99%, ≥99%ee, de
Product Unit SizeCostQuantityStock
1 mg $87.20 In stock
5 mg $157.80 In stock
25 mg $413.30 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LCL-161 is a second mitochondria-derived activator of caspases (SMAC) mimetic that binds to cIAP1 and cIAP2 (members of the inhibitors of apoptosis family of proteins, often upregulated in many cancers) and initiates their destruction. This compound exhibits anticancer chemotherapeutic activity by inducing apoptosis in in vitro models of lymphoid cancers. LCL-161 also activates human PXR and induces activity of CYP3A4/5.

Product Info

Cas No.

1005342-46-0

Purity

≥99%, ≥99%ee, de

Formula

C26H33FN4O3S

Formula Wt.

500.63

IUPAC Name

(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide

Synonym

LCL161

Solubility

DMSO 100 mg/mL (199.74 mM) Ethanol 20 mg/mL warmed (39.94 mM) Water Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L1044 MSDS PDF

Info Sheet

L1044 Info Sheet PDF

References

Dhuria S, Einolf H, Mangold J, et al. Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects. J Clin Pharmacol. 2013 Jun;53(6):642-53. PMID: 23585187.

Houghton PJ, Kang MH, Reynolds CP, et al. Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer. 2012 Apr;58(4):636-9. PMID: 21681929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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