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Levofloxacin is the S-(−) isomer of ofloxacin. Levofloxacin is a fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV; it exhibits antibacterial efficacy against gram negative and gram positive bacteria. Levofloxacin also displays anticancer activity, as when complexed with gold(III), it binds DNA and inhibits cellular proliferation in several cancer cell lines.
| Cas No. | 138199-71-0 |
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| Purity | ≥98% |
| Formula | (C18H20FN3O4)2 • H2O |
| Formula Wt. | 370.4 |
| IUPAC Name | (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrate |
| Synonym | S-(−)-Ofloxacin, |
| Appearance | Slight yellow crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Fu Y, Zhang W, Wang H, et al. Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli. BMC Infect Dis. 2013 Jan 7;13:8. PMID: 23295059.
Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.
Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.