LKT Labs

Biochemicals for Life Science Research

Linagliptin

Linagliptin

Product ID L337521
Cas No. 668270-12-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $45.30 In stock
10 mg $60.10 In stock
25 mg $105.30 In stock
50 mg $180.30 In stock
Bulk Quote

Quicklinks

Description

Linagliptin is a dipeptidyl peptidase 4 inhibitor glucose-lowering compound with low risk of inducing hypoglycaemia. It has been found that linagliptin may modify several measures of microvascular function including hyperaemia area, resting blood flow, and peak blood flow in the fasting state. Treatment of STZ-diabetic Wistar rats was shown to decreases levels of oxidative stress, protect against microvascular damage, enhance neuronal cell survival, and prevent vasoregression.
Furthermore, treatment was found to decrease aortic pulse wave velocity, glycated haemoglobin, fasting plasma glucose, and triglycerides in people with early type 2 diabetes. Contrarily, linagliptin has also been known to cause adverse reactions such as ulcers and blisters.

Product Info

Cas No.

668270-12-0
Purity

≥98%
Formula

C25H28N8O2
Formula Wt.

472.55
Chemical Name

8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
IUPAC Name

8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-3,7-dihydro-1H-purine-2,6-dione
Synonym

Tradjenta, BI 1356, Ondero
Solubility

Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (1 mg/ml at 25 °C), 0.5% hyroxyethylcellulose (30 mg/ml at 25 °C), and methanol.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L337521 MSDS PDF
Info Sheet

L337521 Info Sheet PDF

References

Jax T, Stirban A, Terjung A, et al. A randomized, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes. Cardiovasc Diabetol. 2017 Jan 21;16(1):13. PMID: 28109295.

Dietrich N, Kolibabka M, Busch S, et al. The DPP4 inhibitor linagliptin protects from experimental diabetic retinopathy. PLoS One. 2016 Dec 12;11(12):e0167853. PMID: 27942008.

de Boer SA, Heerspink HJL, Juarez Orozco LE, et al. Effect of linagliptin on pulse wave velocity in early type 2 diabetes: a randomized, double-blind, controlled 26-week trial (RELEASE). Diabetes Obes Metab. 2017 Aug;19(8):1147-1154. PMID: 28244635.

Psomadakis C, Shahzad N, Katz J. Linagliptin-associated blistering and ulceration. BMJ Case Rep. 2017 May 31;2017. PMID: 28566414.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9615

    Cyclosporin B

    Cyclic peptide; calcineurin inhibitor.

    ≥95%
  • R2816

    Recombinant HIV-2 gp36

    Recombinant HIV-1 glycoprotein antigen fragment...

    ≥95%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • S881011

    Swainsonine

    Antineoplastic immunomodulator.

    ≥98%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • T1852

    Tenovin-1

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • A2420

    A-769662

    AMPK activator.

    ≥98%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • F3208

    Fibrinopeptide B, human

    Antimicrobial peptide, generated during fibrin ...

    ≥95%
  • N3323

    Nifuratel

    Nitrofuran derivative.

    ≥99%
  • T3468

    Tirapazamine

    Topoisomerase II inhibitor, RPA modulator.

    ≥98%
  • T1008

    10,13-Bissidechain Paclitaxel

    Synthesis impurity

    ≥90%
  • Z0944

    ZCL-278

    Cdc42 inhibitor.

    ≥98%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%
  • M1979

    Methyl Salicylate

    Ester found in Spiraea, Betula, and Gaultheria;...

    ≥98%
  • A464766

    Altenuene

    Alternaria mycotoxin which may be found in food...

    ≥98%
  • T1670

    Terazosin Hydrochloride Dihydrate

    Quinazoline; α1-adrenergic antagonist.  
    ≥98%
  • A990144

    AZD4320

    Inhibitor of Bcl-2 and Bcl-xL

    ≥99%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • R0245

    Raltitrexed

    Folate analog; thymidylate synthase inhibitor.<...

    ≥98%