LKT Labs

Biochemicals for Life Science Research

Loratadine

Loratadine

Product ID L5767
Cas No. 79794-75-5
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $86.80 In stock
1 g $132.30 In stock
5 g $520.60 In stock
Bulk Quote

Quicklinks

Description

Loratadine is a non-sedating antihistaminergic that acts as an antagonist at histamine H1 receptors that exhibits anti-inflammatory, anti-allergic, anti-asthma, and anticancer chemotherapeutic activities. Loratadine is clinically used to treat allergic rhinitis, chronic idiopathic urticaria, and asthma. In vivo, loratadine inhibits growth of colon cancer xenografts through decreases expression of cyclin B1 and Chk1, the induction of G2/M phase cell cycle arrest, and direct damage to DNA. Loratadine also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

79794-75-5
Purity

≥98%
Formula

C22H23ClN2O2
Formula Wt.

382.88
Chemical Name

4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta- [1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
IUPAC Name

ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridin-11-ylidene)piperidine-1-carboxylate
Synonym

Claritin, Lisino
Melting Point

134-136°C
Solubility

Soluble in DMSO (26mg/mL). Insoluble in water.
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L5767 MSDS PDF
Info Sheet

L5767 Info Sheet PDF

References

Soule BP, Simone NL, DeGraff WG, et al. Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol. 2010 Feb 3;5:8. PMID: 20128919.

DuBuske LM. Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. Expert Opin Pharmacother. 2005 Nov;6(14):2511-23. PMID: 16259582.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B0150

    Bambuterol Hydrochloride

    β2-adrenergic agonist, BChE inhibitor.

    ≥98%
  • M2076

    Metformin Hydrochloride

    AMPK activator.

    ≥98%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • P3440

    PIK-293

    p110δ PI3K inhibitor.

    ≥98%
  • G0152

    Ganciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • F3209

    Fibronectin-Binding Protein

    Peptide, binds fibronectin.

    ≥95%
  • B1992

    Bexarotene

    RXR agonist.

    ≥98%
  • D3209

    Diclofenac Sodium

    NSAID; COX-1/2 inhibitor, potential K+ channel ...

    ≥99%
  • R1879

    Retinyl Palmitate

    Vitamin A derivative, palmitic acid ester of re...

    ≥1.70 MIU/g, bio assay
  • N3213

    Nidulal

    Sesquiterpene found in Nidula.

    ≥95%
  • A7672

    Atropine Sulfate Monohydrate

    Tropane alkaloid found in Solanaceae plants; mA...

    ≥98%
  • Z0222

    Zafirlukast

    VEGF-C/Nrp2 inhibitor. Leukotriene receptor ant...

    ≥98%
  • F4480

    5-Fluorouracil

    Pyrimidine analog; inhibits thymidylate synthas...

    ≥98%
  • S336486

    Simeprevir

    NS3/4A inhibitor

    ≥99%
  • B0133

    Baicalin

    Flavone found in Scutellaria; prolyl oligopepti...

    ≥95%
  • B6959

    Bromosporine

    BRD2/4/9 and CECR2 inhibitor.

    ≥99%
  • A761003

    AT-7519 Hydrochloride

    ATP competitive CDK inhibitor.

    ≥98%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C179603

    CEP-37440 Hydrochloride

    Inhibitor of FAK and ALK.

    ≥99%