Losartan Potassium

Name: Losartan Potassium
SKU: L5873
Availability: InStock

Product ID L5873

Cas No. 124750-99-8

Purity ≥98%

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Description

Losartan is an inhibitor of the angiotensin II type 1 (AT1) receptor that exhibits antihypertensive, anti-fibrotic, and nephroprotective activities. In animal models of obstructive nephropathy, losartan decreases levels of α-SMA and collagen type 1 and inhibits phosphorylation of STAT3, suppressing renal tubular fibrosis. Losartan also inhibits the endothelial-to-mesenchymal transition through indirect inhibition of ERK activation, potentially showing anti-fibrotic benefit after myocardial infarction.

Product Info

Cas No.	124750-99-8
Purity	≥98%
Formula	C₂₂H₂₂ClN₆O K
Formula Wt.	461.01
Chemical Name	2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt
IUPAC Name	potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2, 3-triaza-4-azanidacyclopenta-2, 5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Synonym	DuPont-753, Losaprex, Lortaan, Neo-Lotan, Oscaar
Melting Point	263-265°C
Solubility	Soluble in water to 100 mM, DMSO to 100 mM, and alcohol.
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L5873 MSDS PDF
Info Sheet	L5873 Info Sheet PDF

References

He P, Li D, Zhang B. Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy. Mol Med Rep. 2014 Aug;10(2):638-44. PMID: 24912579.

Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5. PMID: 24632204.

Gibson TJ. Hypertension, its treatment, hyperuricaemia and gout. Curr Opin Rheumatol. 2013 Mar;25(2):217-22. PMID: 23370375.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

Nagata T, Fukuzawa T, Takeda M, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-531. PMID: 23751087.

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Losartan Potassium

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