LKT Labs

Biochemicals for Life Science Research

Lycorine Hydrochloride

Lycorine Hydrochloride

Product ID L9610
Cas No. 2188-68-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $82.00 In stock
25 mg $155.00 In stock
100 mg $455.70 In stock
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Description

Lycorine is an alkaloid found in plants in the Amaryllidaceae family; it exhibits antifungal, anti-parasitic, and anticancer activities. Lycorine inhibits protein synthesis by preventing amino acid incorporation info proteins, potentially through the inhibition of peptidyltransferases. Lycorine inhibits the growth of many fungi, including Fusarium. Additionally, lycorine induces cell cycle arrest and cell death in Trichomonas. This compound also induces G0/G1 phase cell cycle arrest, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, and inhibits growth in chromic myelogenous leukemia (CML) cells.

Product Info

Cas No.

2188-68-3
Purity

≥98%
Formula

C16H17NO4 • HCl
Formula Wt.

323.77
IUPAC Name

(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride
Synonym

Lycorine HCl
Solubility

Soluble in water (>15 mg/ml), DMSO, and ethanol
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

L9610 MSDS PDF
Info Sheet

L9610 Info Sheet PDF

References

Shen JW, Ruan Y, Ren W, et al. Lycorine: a potential broad-spectrum agent against crop pathogenic fungi. J Microbiol Biotechnol. 2014 Mar 28;24(3):354-8. PMID: 24346469.

Li L, Dai HJ, Ye M, et al. Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition. Cancer Cell Int. 2012 Nov 23;12(1):49. PMID: 23176676.

Giordani RB, Vieira Pde B, Weizenmann M, et al. Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway. Phytochemistry. 2011 May;72(7):645-50. PMID: 21324496.

Yui S, Mikami M, Mimaki Y, et al. Inhibition effect of Amaryllidaceae alkaloids, lycorine and lycoricidinol on macrophage TNF-alpha production. Yakugaku Zasshi. 2001 Feb;121(2):167-71. PMID: 11218731.

Kukhanova M, Victorova L, Krayevsky A. Peptidyltransferase center of ribosomes. On the mechanism of action of alkaloid lycorine. FEBS Lett. 1983 Aug 22;160(1-2):129-33. PMID: 6350039.

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