Description
Magainin 1 is a membrane-disruptive antimicrobial/antibacterial peptide (AMP) initially produced by African frogs. Magainin 1 exhibits antibacterial activity, inhibiting growth of gram positive bacteria by forming ion channels in bacterial membranes and altering membrane permeability; this prevents bacterial adhesion to membranes and inhibits bacterial growth. Magainin 1 also displays potential anticancer benefit in mammalian leukemia cells, increasing levels of ROS and release of cytochrome c and inducing apoptosis.