LKT Labs

Biochemicals for Life Science Research

Magainin 1

Magainin 1

Product ID M0124
Cas No. 108433-99-4
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $79.00 Please Inquire
1 mg $126.00 Please Inquire
2.5 mg $263.00 Please Inquire
Bulk Quote

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Description

Magainin 1 is a membrane-disruptive antimicrobial/antibacterial peptide (AMP) initially produced by African frogs. Magainin 1 exhibits antibacterial activity, inhibiting growth of gram positive bacteria by forming ion channels in bacterial membranes and altering membrane permeability; this prevents bacterial adhesion to membranes and inhibits bacterial growth. Magainin 1 also displays potential anticancer benefit in mammalian leukemia cells, increasing levels of ROS and release of cytochrome c and inducing apoptosis.

Product Info

Cas No.

108433-99-4
Purity

≥95%
Formula

C112H177N29O28S
Formula Wt.

2409.9
Solubility

Soluble in water or 1% acetic acid (1 mg/mL)(clear colorless solution).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M0124 MSDS PDF
Info Sheet

M0124 Info Sheet PDF

References

Humblot V, Yala JF, Thebault P, et al. The antibacterial activity of Magainin I immobilized onto mixed thiols Self-Assembled Monolayers. Biomaterials. 2009 Jul;30(21):3503-12. PMID: 19345992.

Cruz-Chamorro L, Puertollano MA, Puertollano E, et al. In vitro biological activities of magainin alone or in combination with nisin. Peptides. 2006 Jun;27(6):1201-9. PMID: 16356589.

Mozsolits H, Wirth HJ, Werkmeister J, et al. Analysis of antimicrobial peptide interactions with hybrid bilayer membrane systems using surface plasmon resonance. Biochim Biophys Acta. 2001 May 2;1512(1):64-76. PMID: 11334625.

Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim Biophys Acta. 1999 Dec 15;1462(1-2):1-10. PMID: 10590299.

Cruciani RA, Barker JL, Durell SR, et al. Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes.

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