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MC1568

MC1568

Product ID M0803
Cas No. 852475-26-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $147.20 In stock
25 mg $525.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MC1568 interferes with myogenic signaling by blocking HDAC enzymatic activity and MEF2-mediated transactivation in C2C12 cells. Exposure of rat intestinal epithelial cell line EIC-18 to MC1568 prevented stimulation of DNA synthesis and blocked cell cycle progression in the G0/G1 phase. In a mice carotid ligation model, MC1568 has been shown to mediate proliferation and migration of smooth muscle cells in vitro, and thus may reduce blood pressure in hypertensive animals.

Product Info

Cas No.

852475-26-4

Purity

≥98%

Formula

C17H15FN2O3

Formula Wt.

314.32

Chemical Name

(2E)-3-{4-[(1E)-3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl}-N-hydroxyacrylamide

IUPAC Name

(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide

Synonym

Hdac-IN-1

Solubility

100mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M0803 MSDS PDF

Info Sheet

M0803 Info Sheet PDF

References

Nebbioso A, Manzo F, Miceli M, et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-782. PMID: 19498465.

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-C971. PMID: 24647541.

Usui T, Morita T, Okada M, Yamawaki H. Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 2014 Feb;63(2):397-403. PMID: 24166750.

Lemon DD, Harrison BC, Horn TR, et al. Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle. FEBS Lett. 2015 Apr 28;589(10):1080-1088. PMID: 25816750.

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