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Mecamylamine Hydrochloride

Mecamylamine Hydrochloride

Product ID M1708
Cas No. 826-39-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $77.70 In stock
25 mg $281.60 In stock
100 mg $901.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mecamylamine is a reversible, non-competitive, non-selective inhibitor of nicotinic acetylcholine receptors (nAChRs); it decreases channel open time and burst duration. This compound exhibits antihypertensive, antidepressant, and anxiolytic activities. Mecamylamine crosses the blood-brain barrier and acts both centrally and peripherally, resulting in high incidence of peripheral side effects. Mecamylamine was previously clinically used to decrease blood pressure, but also reduces mood instability and depression in subjects with Tourette’s syndrome and shows potential benefit as a smoking cessation therapy. In animals, mecamylamine improves activity in the forced swim test, social interaction tests, and light/dark paradigms.

Product Info

Cas No.

826-39-1

Purity

≥98%

Formula

C11H21N • HCl

Formula Wt.

203.75

IUPAC Name

N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine;hydrochloride

Synonym

inversine, 2-(methylamino)isocamphane hydrochloride, N,2,3,3-tetramethyl-2-norbornanamine, N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Melting Point

245.5-246.5°C (dec)

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1708 MSDS PDF

Info Sheet

M1708 Info Sheet PDF

References

Peng C, Kimbrell MR, Tian C, et al. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Mol Pharmacol. 2013 Sep;84(3):459-75. PMID: 23839567.

Sanberg PR, Vindrola-Padros C, Shytle RD. Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiol Behav. 2012 Dec 5;107(5):801-8. PMID: 22776623.

LeSage MG, Shelley D, Pravetoni M, et al. Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. PMID: 22503967.

Bacher I, Wu B, Shytle DR, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21. PMID: 19874251.

Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008 Winter;14(4):266-77. PMID: 19040552.

Shytle RD, Penny E, Silver AA, et al. Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7. PMID: 12080428.

Hayashi E, Yamada S, Mori M. Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum. Jpn J Pharmacol. 1977 Oct;27(5):659-65. PMID: 592556.

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