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Meropenem is a β-lactam antibiotic that belongs to the family of carbapenems, active against all bacteria, with the most significant antibacterial activity against gram-negative species. Meropenem is somewhat resistant to degradation by β-lactamases and is used to treat bacterial meningitis, skin infections, and febrile neutropenia. This compound inhibits bacterial cell wall synthesis by binding penicillin-binding proteins 2 and 3 (PBP2/3), preventing formation of peptidoglycan.
| Cas No. | 119478-56-7 |
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| Purity | ≥98% |
| Formula | C17H25N3O5S • 3H2O |
| Formula Wt. | 437.51 |
| Chemical Name | (4R,5S,6S)-3-[(3S, 5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate |
| IUPAC Name | (4R,5S,6S)-3-[(3S, 5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate |
| Synonym | Merrem I.V. |
| Appearance | White to slightly yellow powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mallick M, Odedra D, Vidyarthi AS, et al. Meropenem: a potent drug against superbug as unveiled through bioinformatics approaches. Int J Bioinform Res Appl. 2013;9(2):109-20. PMID: 23467058.
Pernot L, Frénois F, Rybkine T, et al. Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem. J Mol Biol. 2001 Jul 20;310(4):859-74. PMID: 11453693.
Sumita Y, Fukasawa M. Potent activity of meropenem against Escherichia coli arising from its simultaneous binding to penicillin-binding proteins 2 and 3. J Antimicrob Chemother. 1995 Jul;36(1):53-64. PMID: 8537284.