LKT Labs

Biochemicals for Life Science Research

Methyl Caffeate

Methyl Caffeate

Product ID M1560
Cas No. 3843-74-1
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $84.00 In stock
100 mg $150.00 In stock
500 mg $454.00 In stock
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Description

Methyl caffeate is a polyphenol found in species of Solanum and Magnolia; it exhibits antibiotic, anti-diabetic, antiviral, and anticoagulant activities. Methyl caffeate displays antibacterial efficacy against Pseudomonas, Klebsiella, and Mycobacterium. This compound also inhibits HIV replication and displays antiplatelet activity in various in vitro models. In diabetic rats, methyl caffeate decrease blood glucose levels and upregulates expression of GLUT4; it also inhibits α-glucosidase. Methyl caffeate exhibits weaker anticancer and chemopreventive activities than other caffeic acid esters.

Product Info

Cas No.

3843-74-1
Purity

≥98%
Formula

C10H10O4
Formula Wt.

194.19
Chemical Name

Methyl 3-(3,4-dihydroxyphenyl)-2-propenoate
IUPAC Name

methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Synonym

3,4-Dihydroxycinnamic acid methylester
Melting Point

163-165°C
Solubility

Soluble in acetone, methanol, or DMSO.
Appearance

Slightly yellowish solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M1560 MSDS PDF
Info Sheet

M1560 Info Sheet PDF

References

Balachandran C, Duraipandiyan V, Al-Dhabi NA, et al. Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit. Indian J Microbiol. 2012 Dec;52(4):676-81. PMID: 24293730.

Gandhi GR, Ignacimuthu S, Paulraj MG, et al. Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats. Eur J Pharmacol. 2011 Nov 30;670(2-3):623-31. PMID: 21963451.

Takahashi K, Yoshioka Y, Kato E, et al. Methyl caffeate as an alpha-glucosidase inhibitor from Solanum torvum fruits and the activity of related compounds. Biosci Biotechnol Biochem. 2010;74(4):741-5. PMID: 20378981.

Ho CC, Lin SS, Chou MY, et al. Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo. J Antimicrob Chemother. 2005 Aug;56(2):372-9. PMID: 16002419.

Pyo MK, Lee Y, Yun-Choi HS. Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch Pharm Res. 2002 Jun;25(3):325-8. PMID: 12135105.

Rao CV, Desai D, Kaul B, et al. Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth. Chem Biol Interact. 1992 Nov 16;84(3):277-90. PMID: 1423745.

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