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Methylisoindigotin

Methylisoindigotin

Product ID M3232
Cas No. 97207-47-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $84.40 In stock
50 mg $303.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Methylisoindigotin is an indirubin derivative that displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. In vitro, methylisoindigotin inhibits growth and proliferation of various leukemia cell lines. In LPS-stimulated macrophages and keratinocytes, methylisoindigotin decreases production of NO and pro-inflammatory cytokines. This compound also induces apoptosis and inhibits tumor growth in animal models of colon adenocarcinoma. In other models, methylisoindigotin decreases GSK expression and downregulates Wnt activity. Additionally, methylisoindigotin decreases production of VEGF and suppresses tube formation in vitro.

Product Info

Cas No.

97207-47-1

Purity

≥98%

Formula

C17H12N2O2

Formula Wt.

276.30

Chemical Name

1-Methyl-3,3'-biindole-2,2'(1H,1'H)-dione

IUPAC Name

(3E)-1-Methyl-3-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1,3-dihydro-2H-indol-2-one

Synonym

Meisoindigo, 4-Methylisoindigotin

Solubility

DMSO: ≥ 51 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M3232 MSDS PDF

Info Sheet

M3232 Info Sheet PDF

References

Huang M, Lin HS, Lee YS, et al. Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. Int J Oncol. 2014 Oct;45(4):1724-34. PMID: 25050545.

Zhang HJ, Zhang Y, Jin J, et al. Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways. Yao Xue Xue Bao. 2013 Apr;48(4):503-7. PMID: 23833936.

Zuo MX, Li Y, Zhou JH, et al. Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):579-82. PMID: 20561405.

Mingxin Z, Yan L, Hongbo W, et al. The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. J Chemother. 2008 Dec;20(6):728-33. PMID: 19129071.

Xiao Z, Wang Y, Lu L, et al. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk Res. 2006 Jan;30(1):54-9. PMID: 15982734.

Custom Order

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