Methysticin

Name: Methysticin
SKU: M1679
Availability: InStock

Product ID M1679

Cas No. 495-85-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Methysticin is a kavalactone originally found in Piper methysticum (kava plant). Methysticin exhibits neuroprotective, neuromodulatory, and antifungal activities. Methysticin may also display anti-inflammatory benefit, inhibiting activation of NF-κB in lung adenocarcinoma tissue. Methysticin activates Nrf2 in neurons and astroglia, protecting against amyloid-β (Aβ)-induced neurotoxicity. This compound displays antimicrobial efficacy against species of Fusarium, Trichoderma, and Colletotrichum. Additionally, methysticin inhibits peak amplitude of voltage-gated Na+ channels in hippocampal neurons.

Product Info

Cas No.	495-85-2
Purity	≥98%
Formula	C₁₅H₁₄O₅
Formula Wt.	274.27
Chemical Name	(6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4-methoxy-2H-pyran-2-one
IUPAC Name	(2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2, 3-dihydropyran-6-one
Synonym	Kavahin, Kavatin
Melting Point	132-134°C
Solubility	Soluble in alcohol, ether or acetone. Practically insoluble in water. Soluble in DMSO (10 mg/mL), hot ethanol (2 mg/mL).
Appearance	White/Off-White Crystalline Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M1679 MSDS PDF
Info Sheet	M1679 Info Sheet PDF

References

Shaik AA, Hermanson DL, Xing C. Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5732-6. PMID: 19716299.

Wruck CJ, Götz ME, Herdegen T, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95. PMID: 18334601.

Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174.

Magura EI, Kopanitsa MV, Gleitz J, et al. Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Neuroscience. 1997 Nov;81(2):345-51. Erratum in: Neuroscience 1998 May;84(1):323. PMID: 9300426.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Methysticin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Gabexate Mesylate

LY-2603618

Fenbendazole

N,N-Dimethyl-Sphingosine

Diacetoxyscirpenol

Linagliptin

Tamoxifen Citrate

Bactenecin

Bongkrekic Acid

Thienyloctyl Isothiocyanate

n-Octyl Caffeate

Nabumetone

Tanshinone IIA

Tacrolimus

(+)-Ketanserin Tartrate

N-Des-2-methylpropan-2-ol Docetaxel

Thiamine Mononitrate

Rutin Hydrate

Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

Z-VAD-FMK

Footer