LKT Labs

Biochemicals for Life Science Research

MRTX1719

MRTX1719

Product ID M704793
Cas No. 2630904-45-7
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $215.00 In stock
5 mg $589.90 In stock
10 mg $1,086.00 In stock
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Description

MRTX1719 is an inhibitor of the PRMT5/MTA complex and may be effective against MTAP-deleted cancers.

Product Info

Cas No.

2630904-45-7
Purity

≥95%
Formula

C23H18ClFN6O2
IUPAC Name

2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile
Synonym

MRTX-1719

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

Info Sheet

M704793 Info Sheet PDF

References

Smith C, Aranda R, Christensen J, et al. Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors. Bioorg Med Chem. 2022 Oct 1;71:116947. PMID: 35926325

Smith C, Aranda R, Bobinski T, et al. Fragment-based discovery of MRTX1719, a synthetic lethal inhibitor of the PRMT5.MTA complex for the treatment of MTAP-deleted cancers. J Med Chem. 2022 Feb 10;65(3):1749-1766. PMID: 35041419

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