Description
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
| Cas No. | 1395084-25-9 |
|---|---|
| Purity | ≥99% |
| Formula | C18H17N5O3S |
| Formula Wt. | 383.43 |
| IUPAC Name | 4-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(2-pyridinyl)benzenesulfonamide |
| Solubility | 100mM in DMSO |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283.
Toxin found in Aconitum; voltage-gated Na+ chan...
β-adrenergic antagonist.
Triazole; 14α demethylase inhibitor.
Endogenous calcitonin-family peptide, involved ...
Fluoroquinolone; topoisomerase IV and bacterial...
BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.
Taxane found in Taxus; potential microtubule de...
MEK1/2 inhibitor.
Non-selective CB receptor agonist.
Dihydrofolate reductase inhibitor.
Endogenous peptide neurotransmitter, involved i...
Inhibitor of EGFR, HER2, and HER3.
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Synthesis impurity
Wortmannin analog; PI3K inhibitor.
Sulfonamide; PABA inhibitor.
Peptide, involved in synapse formation and cell...
PI3K inhibitor.
Phenol found in Zingiber; 5-HT3 antagonist.
Estradiol metabolite; microtubule depolymerizat...