Description
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
| Cas No. | 1395084-25-9 |
|---|---|
| Purity | ≥99% |
| Formula | C18H17N5O3S |
| Formula Wt. | 383.43 |
| IUPAC Name | 4-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(2-pyridinyl)benzenesulfonamide |
| Solubility | 100mM in DMSO |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283.
Polyanionic sulfated glycosaminoglycan, encogen...
Hydantoin derivative; RyR antagonist, L-type Ca...
Citalopram analog
Nav1.7 and Nav1.8 N1+ channel blocker.
Sulfur analog of furan found in cooked meat pro...
Sulfonamide; carbonic anhydrase inhibitor, volt...
Triterpene saponin found in species of Panax.
CDK4/6 inhibitor.
Bactericidal
B-Raf inhibitor.
Anthraquinone found in aloe; CTFR Cl- channel a...
Arylbenzimidazole; CHK2 inhibitor.
Organosulfur found in garlic; Microtubule polym...
Excitatory amino acid found in seaweed; AMPA an...
Bcl-2, Bcl-xl, sialyl transferase inhibitor.
Peptide; PAR1 agonist.
Imidzoline derivative; MDM2 inhibitor.
Anthraquinone found in Rheum.
Hec1/Nek2 mitotic pathway inhibitor
Peptide; GABA potentiator, NMDA negative allost...