Description
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
| Cas No. | 1395084-25-9 |
|---|---|
| Purity | ≥99% |
| Formula | C18H17N5O3S |
| Formula Wt. | 383.43 |
| IUPAC Name | 4-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(2-pyridinyl)benzenesulfonamide |
| Solubility | 100mM in DMSO |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283.
Thienylbutyl ITC analog.
Diterpene found in Taxus; potential microtubule...
Viral RNA polymerase inhibitor.
Antifungal antibiotic
AhR agonist, dihydroorotate dehydrogenase inhib...
Degrader of IKZF1/3
Antimicrobial peptide.
Imaging agent; Maillard reaction inhibitor.
Triazole; 14α demethylase inhibitor.
MGMT inhibitor.
Tetracycline; protein translation inhibitor, MM...
Protein translation inhibitor.
Cathepsin K inhibitor.
Terpene lactone found in Ginkgo; GlyR antagonis...
JAK1/2 inhibitor.
NSAID; COX-1/2 and lipoxygenase inhibitor.
Selective positive allosteric modulator of AMPA...
Flavonol found in Tagetes.
Organosulfur found in garlic; Microtubule polym...
Synthesis intermediate