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N-Acetyl-S-(N′-methylthiocarbamoyl)-L-cysteine

N-Acetyl-S-(N′-methylthiocarbamoyl)-L-cysteine

Product ID A0823
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $113.30 Please Inquire
25 mg $201.20 Please Inquire
100 mg $616.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

N-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteine (AMITC) is a cysteine conjugate of N-acetyl-methylisothiocyanate. AMITC is a pesticide typically used to fumigate wheat and other grain crops, killing pests such as grain beetles and weevils. AMITC also exhibits anti-parasitic activity, inhibiting the hatch of nematodes from species of Heterodera and decreasing the population density of species of Meloidogyne. This compound inhibits mitochondrial aldehyde dehydrogenase in the liver, increasing aldehyde levels in blood and brain in vivo. Additionally, AMITC displays genotoxic potential, inducing lipid peroxidation-mediated DNA damage at high doses.

Product Info

Purity

≥98%

Formula

C7H12N2O3S2

Formula Wt.

236.31

Chemical Name

2-acetamido-3-(methylcarbamothioylsulfanyl)propanoic acid

IUPAC Name

2-acetamido-3-(methylcarbamothioylsulfanyl)propanoic acid

Synonym

Acetyl methylisothiocyanate-L-cysteine

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0823 MSDS PDF

Info Sheet

A0823 Info Sheet PDF

References

Ren Y, Lee B, Mahon D, et al. Fumigation of wheat using liquid ethyl formate plus methyl isothiocyanate in 50-tonne farm bins. J Econ Entomol. 2008 Apr;101(2):623-30. PMID: 18459432.

Kassie F, Laky B, Nobis E, et al. Genotoxic effects of methyl isothiocyanate. Mutat Res. 2001 Jan 25;490(1):1-9. Erratum in: Mutat Res 2001 May 31;492(1-2):111-3. PMID: 11152966.

Staub RE, Sparks SE, Quistad GB, et al. S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Chem Res Toxicol. 1995 Dec;8(8):1063-9. PMID: 8605289.

Greco N, Elia F, Brandonisio A. Control of Heterodera carotae, Ditylenchus dipsaci, and Meloidogyne javanica with Fumigant and Nonfumigant Nematicides. J Nematol. 1986 Jul;18(3):359-63. PMID: 19294191.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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