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This compound is an N-acetyl cysteine conjugate of phenethylisothiocyanate (PEITC-NAC), exhibiting anticancer chemotherapeutic and chemopreventive activities. In lung cancer and prostate cancer models, PEITC-NAC increases activation of JNK, p53, and MAPKs, inducing apoptosis, decreasing tumor growth, and limiting tumorigenesis.
| Cas No. | 131918-97-3 |
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| Purity | ≥95% |
| Formula | C14H18N2O3S2 |
| Formula Wt. | 326.43 |
| Chemical Name | Phenethyl isothiocyanate N-acetyl-L-cysteine conjugate; PEITC N-acetyl-L-cysteine conjugate |
| IUPAC Name | (2R)-2-acetamido-3-(2-phenylethylcarbamothioylsulfanyl)propanoic acid |
| Synonym | PEITC-NAC |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kassie F, Melkamu T, Endalew A, et al. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis. 2010 Sep;31(9):1634-41. PMID: 20603442.
Yang YM, Conaway CC, Chiao JW, et al. Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res. 2002 Jan 1;62(1):2-7. PMID: 11782348.
Chiao JW, Chung F, Krzeminski J, et al. Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate. Int J Oncol. 2000 Jun;16(6):1215-9. PMID: 10811998.