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N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

Product ID A0902
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $214.00 In stock
25 mg $465.30 In stock
100 mg $1,459.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteine (PHITC) is a cysteine conjugate of N-acetyl-phenylhexylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, PHITC increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione-S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of CDK inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

Product Info

Purity

≥98%

Formula

C18H26N2O3S2

Formula Wt.

382.54

Chemical Name

N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

Synonym

Acetyl phenylhexylisothiocyanate -L-cysteine

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0902 MSDS PDF

Info Sheet

A0902 Info Sheet PDF

References

Lu Q, Lin X, Feng J, et al. Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol. 2008 Jun 9;1:6. PMID: 18577263.

Lu L, Liu D, Ma X, et al. The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. Oncol Rep. 2006 Dec;16(6):1363-7. PMID: 17089062.

Morse MA, Eklind KI, Hecht SS, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991 Apr 1;51(7):1846-50. PMID: 2004368.

Custom Order

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