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Necrostatin-1

Necrostatin-1

Product ID N1610
Cas No. 4311-88-0
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $67.60 In stock
25 mg $168.80 In stock
100 mg $506.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Necrostatin-1 is an inhibitor of receptor interacting protein 1 (RIP1), preventing necroptosis, a programmed cell death. Necrostatin-1 exhibits nephroprotective, neuroprotective, and cytoprotective activities. In animal models of chronic kidney disease, necrostatin-1 improves renal function and pathology by preventing loss of renal cells. Necrostatin-1 also prevents death of hippocampal neurons in animal models of cerebral ischemia.

Product Info

Cas No.

4311-88-0

Purity

≥99%

Formula

C13H13N3OS

Formula Wt.

259.33

IUPAC Name

5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Solubility

Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml).

Appearance

Off-white to yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1610 MSDS PDF

Info Sheet

N1610 Info Sheet PDF

References

Zhu Y, Cui H, Gan H, et al. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 2015 Jun 12;461(4):575-81. PMID: 25907058.

Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015 Jun 3;1609:63-71. PMID: 25801119.

Steinwascher S, Nugues AL, Schoeneberger H, et al. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett. 2015 May 28. [Epub ahead of print]. PMID: 26028172.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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