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Neuromedin U, rat

Neuromedin U, rat

Product ID N1982
Cas No. 117505-80-3
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $89.30 In stock
2 mg $157.50 In stock
5 mg $315.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Neuromedin U is an endogenous neurohormone involved in maintenance of energy homeostasis. Neuromedin U exhibits anorexigenic, thermogenic, anxiolytic, hypertensive, and pro-inflammatory activities. In seasonal animals, neuromedin U increases core temperature and decreases food intake and body weight; these activities are mediated through activation of Wnt/β-catenin signaling. Neuromedin U exhibits anxiolytic benefit in animals undergoing the elevated plus maze test. Neuromedin U also inhibits gastric acid secretion and increases heart rate and blood pressure. Neuromedin U binds neuromedin receptors in ovarian cells, increasing production of progesterone. Additionally, this hormone upregulates inflammation-related cytokine gene expression in vitro in response to bacterial and viral pathogens.

Product Info

Cas No.

117505-80-3

Purity

≥95%

Formula

C124H180N34O31

Formula Wt.

2643.03

IUPAC Name

L-Tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-α-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arg inyl-L-prolyl-L-arginyl-L-aspartamide

Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1982 MSDS PDF

Info Sheet

N1982 Info Sheet PDF

References

Helfer G, Ross AW, Morgan PJ. Neuromedin U partly mimics thyroid stimulating hormone and triggers Wnt/β-Catenin signalling in the photoperiodic response of F344 rats. J Neuroendocrinol. 2013 Oct 24. [Epub ahead of print]. PMID: 24164054.

Telegdy G, Adamik A. Anxiolytic action of neuromedin-U and neurotransmitters involved in mice. Regul Pept. 2013 Sep 10;186:137-40. PMID: 23892031.

Lin TY, Wu FJ, Lee WY, et al. Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2. Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E800-9. PMID: 23423171.

Rahman AA, Shahid IZ, Pilowsky PM. Differential cardiorespiratory and sympathetic reflex responses to microinjection of neuromedin U in rat rostral ventrolateral medulla. J Pharmacol Exp Ther. 2012 Apr;341(1):213-24. PMID: 22262923.

Kono T, Hamasuna S, Korenaga H, et al. The role of neuromedin U during inflammatory response in the common carp. Fish Shellfish Immunol. 2012 Jan;32(1):151-60. PMID: 22122861.

Custom Order

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