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Nicardipine

Nicardipine

Product ID N3208
Cas No. 55985-32-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 g $75.30 In stock
5 g $251.50 In stock
25 g $629.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nicardipine is a dihydropyridine L-type Ca2+ channel blocker that displays antihypertensive, vasodilatory, and antinociceptive activities. In animal models, it also displays neuromodulatory and cognition enhancing activities, inhibiting amygdala kindling and enhancing GABA signaling. Separately, it increases the pain threshold during tests of mechanical pain and prevents hypoxia-induced memory impairment.

Product Info

Cas No.

55985-32-5

Purity

≥99%

Formula

C26H29N3O6

Formula Wt.

479.52

Chemical Name

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

IUPAC Name

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Synonym

Nicardipinum

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N3208 MSDS PDF

Info Sheet

N3208 Info Sheet PDF

References

Yue W, Wang L, Zhang F, et al. Inhibition of nicardipine on amygdala kindling in rats. Acta Pharmacol Sin. 2001 Apr;22(4):365-8. PMID: 11742591.

Eraković V, Zupan G, Mrsić J, et al. The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):633-47. PMID: 9194145.

Mashimo T, Pak M, Choe H, et al. Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1 on primary afferent nociceptors in humans. J Clin Pharmacol. 1997 Apr;37(4):330-5. PMID: 9115059.

Kanneganti M, Halpern NA. Acute hypertension and calcium-channel blockers. New Horiz. 1996 Feb;4(1):19-25. PMID: 8689271.

Custom Order

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