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Nifedipine is a dihydropyridine that acts as an antagonist at L-type Ca2+ channels. Nifedipine exhibits antihypertensive, anti-anginal, cardioprotective, tocolytic, and analgesic activities. This compound is clinically used in the treatment of angina and to prevent preterm labor in pregnant females. Additionally, nifedipine alters pain thresholds in the tail withdrawal electric stimulation test.
| Cas No. | 21829-25-4 |
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| Purity | ≥98% |
| Formula | C17H18N2O6 |
| Formula Wt. | 346.33 |
| Chemical Name | 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5- pyridinedicarboxylic acid dimethyl ester |
| IUPAC Name | dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Synonym | Adalat, Anifed, Aprical, Cordipin, Corotrend, Fenihidine, Nifedicor, Nifensar, Orix, Procardia, Sepamit, Zenusin |
| Melting Point | 172-174°C |
| Solubility | Soluble in DMSO, acetone (100 mg/mL) or ethanol. Insoluble in water. |
| Appearance | Yellow crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Gáspár R, Hajagos-Tóth J. Calcium channel blockers as tocolytics: principles of their actions, adverse effects and therapeutic combinations. Pharmaceuticals (Basel). 2013 May 23;6(6):689-99. PMID: 24276256.
Martín MI, del Val VL, Colado MI, et al. Behavioral and analgesic effects induced by administration of nifedipine and nimodipine. Pharmacol Biochem Behav. 1996 Sep;55(1):93-8. PMID: 8870043.
Zsotér TT, Church JG. Calcium antagonists. Pharmacodynamic effects and mechanism of action. Drugs. 1983 Feb;25(2):93-112. PMID: 6131809.