• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nigericin Sodium

Nigericin Sodium

Product ID N3225
Cas No. 28643-80-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $56.50 In stock
5 mg $137.00 In stock
10 mg $256.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nigericin is an antibiotic found in Streptomyces that exhibits antibacterial activity against gram positive bacteria. Nigericin inhibits Golgi function and viral activation, acting as an antiviral compound. Nigericin also acts as a H+/K+/Pb2+ ionophore. Additionally, this compound displays pro-inflammatory and immunostimulatory activities, triggering activation of the NALP3 inflammasome.

Product Info

Cas No.

28643-80-3

Purity

≥98%

Formula

C40H67O11Na

Formula Wt.

746.94

Chemical Name

Antibiotic K 178 Sodium salt

IUPAC Name

sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R, 6R)-6-hydroxy-6-(hydroxymethyl)-3, 5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7- methoxy-2,4,6-trimethyl-1, 10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate

Synonym

Azalomycin M, Helixin C, Polyetherin A.

Melting Point

245-255°C

Solubility

Soluble in chloroform. Practically insoluble in water.

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N3225 MSDS PDF

Info Sheet

N3225 Info Sheet PDF

References

Heid ME, Keyel PA, Kamga C, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013 Nov 15;191(10):5230-8. PMID: 24089192.

Myskiw C, Piper J, Huzarewich R, et al. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res. 2010 Dec;88(3):304-10. PMID: 20951746.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • D3262

    Dipropyl Sulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • L9704

    LY-2603618

    Chk1 inhibitor.

    ≥98%
  • C0368

    Carveol

    Terpene alcohol found in spearmint oil; TRPV3 a...

    ≥99%
  • E4417

    Eledoisin Related Peptide

    Peptide, substance P analog; NK agonist.

    ≥95%
  • M1979

    Methyl Salicylate

    Ester found in Spiraea, Betula, and Gaultheria;...

    ≥98%
  • M9634

    Myriocin

    Atypical amino acid found in Isaria sinclairi, ...

    ≥99%, TLC
  • B3358

    Biochanin A

    Phytoestrogen, flavonoid found in clover, soy, ...

    ≥98%
  • A5228

    Angiogenin

    Small protein, cleaves RNA.

    ≥98%
  • H1672

    Hesperetin

    Flavanone found in species of Citrus; L-type Ca...

    ≥97%
  • L9701

    LY-450139

    GHS-R1a agonist, γ-secretase inhibitor.

    ≥98%
  • M1613

    Medroxyprogesterone 17-Acetate

    Synthetic steroid used in HRT; PR, AR, glucocor...

    ≥99%
  • N1721

    Nefiracetam

    Pyrrolidone; NMDA and mGluR5 agonist, N-type an...

    ≥98%
  • A6922

    Arformoterol Tartrate

    R,R enantiomer of formoterol; β2-adrenergic an...

    ≥98%
  • D9752

    Dynasore

    Dynamin inhibitor.

    ≥98%
  • C0162

    Capecitabine

    5-FU prodrug; thymidylate synthase inhibitor.

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • N2400

    NG-52

    Purine, purvalenol A analog; CDK2, Cdc28p, Pho8...

    ≥98%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • E5576

    Entecavir

    Nucleoside (deoxyguanosine) analog; DNA chain t...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only