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Nociceptin

Nociceptin

Product ID N5210
Cas No. 170713-75-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $199.50 In stock
2.5 mg $315.00 In stock
5 mg $483.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nociceptin is an endogenous neuropeptide that binds the nociceptin (NOP) receptor, considered the ‘fourth’ opioid receptor subtype. Nociceptin displays anti-opioid activity, modulating nociception and exhibiting anti-analgesic properties in vivo. In the amygdala, nociceptin displays neuromodulatory activity, decreasing glutamate release. Additionally, nociceptin inhibits the activity of POMC neurons and modulates GIRK channel signaling, altering animal mating behavior.

Product Info

Cas No.

170713-75-4

Purity

≥98%

Formula

C79H129N27O22

Formula Wt.

1809.1

Chemical Name

Orphanin FQ

Solubility

Soluble in water, acid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N5210 MSDS PDF

Info Sheet

N5210 Info Sheet PDF

References

Borgquist A, Rivas VM, Kachani M, et al. Gonadal Steroids Differentially Modulate the Actions of Orphanin FQ/Nociceptin at A Physiologically Relevant Circuit Controlling Female Sexual Receptivity. J Neuroendocrinol. 2014 May;26(5):329-40. PMID: 24617903.

Kallupi M, Varodayan FP, Oleata CS, et al. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014 Apr;39(5):1081-92. PMID: 24169802.

Okuda-Ashitaka E, Minami T, Tachibana S, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. PMID: 9521323.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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