Novobiocin Sodium

Name: Novobiocin Sodium
SKU: N5986
Availability: InStock

Product ID N5986

Cas No. 1476-53-5

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Novobiocin is an aminocoumarin antibiotic that inhibits the ATPase activity of the B subunit of bacterial DNA gyrase. Novobiocin is most often used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. In addition to its antibacterial activity, novobiocin also displays anticancer chemotherapeutic and anti-angiogenic properties. Novoboicin inhibits HIF-1α binding to transcriptional coactivator p300/CBP in tumor models and analogs of this compound are in development as HSP90 inhibitors.

Product Info

Cas No.	1476-53-5
Purity	≥98%
Formula	C₃₁H₃₅N₂NaO₁₁
Formula Wt.	634.61
IUPAC Name	sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6, 6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]- 2-(3-methylbut-2-enyl)phenolate
Solubility	50mg/ml in water
Appearance	White Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	N5986 MSDS PDF
Info Sheet	N5986 Info Sheet PDF

References

Gunaherath GM, Marron MT, Wijeratne EM, et al. Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors. Bioorg Med Chem. 2013 Sep 1;21(17):5118-29. PMID: 23859777.

Wu D, Zhang R, Zhao R, et al. A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain. PLoS One. 2013 May 6;8(5):e62014. PMID: 23671581.

Walsh TJ, Standiford HC, Reboli AC, et al. Randomized Double-Blinded Trial of Rifampin with Either Novobiocin or Trimethoprim-Sulfamethoxazole against Methicillin-Resistant Staphylococcus aureus Colonization: Prevention of Antimicrobial Resistance and Effect of Host Factors on Outcome. Antimicrobial agents and chemotherapy 1993 Jun;37(6):1334–42. PMID: 8328783.

Maxwell A. The interaction between coumarin drugs and DNA gyrase. Mol Microbiol 1993;9(4):681–6. PMID: 8231802.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Novobiocin Sodium

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Glucagon, human

Manzamine A

Leupeptin Hemisulfate

Hesperidin

Diclofenac Impurity C

Naringin

Leu-Enkephalin

Mevinolin

MLN2480

Paxilline

Gentamycin Sulfate

Fluocinolone Acetonide

Rifampicin

Tubastatin A Hydrochloride

Hexamethonium Bromide Hydrate

Difenoconazole

Estramustine

Quinapril Hydrochloride

3-Phenylpropyl Isothiocyanate

Quinestrol

Footer